In our case(s), there's a few key differences between our bicycles and our daily-driver cars. Our bikes (most of them) lack a transmission that is variable for the prevailing speed or load, so ugly compromises must be made. Usually, a person sets up their bike, cart, etc to hit top speed on level ground at or close to the HP peak rpm. In our case, I believe the little HS engines make peak hp around 6600-6800 rpm. Most user-verified top speeds for a stock HS equipped bike hover around 33 mph-ish... so for best "top-end" we aim for 6700rpm-ish at 33mph-ish. The problem lies on the bottom end... if geared for a decent top-end, the initial acceleration suffers (like being stuck in 3rd gear in your car in downtown traffic.)
Our cars, on the other hand, have the luxury of variable ratios. Low for starting from a stop, intermediate for reaching top speed in a hurry if need be, and a cruising gear, which enables us to maintain a reasonable speed at an economical rpm for the engine.
I'm not sure if the original Honda (GSX50, I think?) motor has any sort of rev-limiter, but the Huashengs of late DO have a rev limiter that pretty much limits them to a top "cruise" rpm of 6800. I'm guessing they did that because their older engines weren't limited and suffered failures from being held wide open at high rpm. I think we're safe, (at least with the HS142F and 144F) if we don't exceed the rpm cut-off. It's probably still possible if someone descends a long hill with the throttle pinned. I don't have the $$$ to find out, though.