An excellent thread to drag up from the past.
From personal account evidence we have people getting almost zero to thousands of miles from these engines. A common thread is the lower rpm and power demand, the longer life you will receive, barring mechanical or manufacturing defect. Most of the major failures I have heard of have had an aura of performance demand or modification around them. So let's drag up what we know so far:
1) Low power demand and rpm will likely increase the longevity of these engines.
2) High power demand and rpm takes a toll on the life of these engines
3) Modifications tend to introduce a higher possibility of failures because we cannot foresee the consequences of the work done.
This (3) would mean things like damaging the crank or bearings while putting better ones in, grinding not fully cleaned after porting, the lightened pin or piston failing. This takes in Headsmess's suggestion of "If it's not broke, don't touch it" with cranks, especially if you don't know the right bearings to use. As for his advice about using sealed bearngs with inner removed (to solve the seal problem), I'd suggest bearings live longer with a flow of cooling oil by drilling a flow passage from the transfer port. However if this is not done right, you will invoke rule 3). It is a wash which failure is more likely, seals or crank bearing?
Unbalanced cranks are not a problem if the rpm is kept down. Buzz it to no more than 6000rpm like Fabian or LargePilip suggest and crank vibes are not a big problem. Newer Grubee cranks are pretty good, I have good luck with mine to 10,000rpm. That said, the big end bearing is now loose at 2000 miles of that sort ofrthis has been rpm.
Most of this has been said before in:
http://motoredbikes.com/threads/pre...ers-should-do-with-these-2-stroke-kits.11986/
and
http://motoredbikes.com/threads/the-crash-course-for-motoredbike-noobs.10392/
With some bad advice in there too.
I would keep my three rules at the top as a darned good place to start for longevity.
Steve